Towards the Synthesis of the Cornexistins

Abstract

A concise synthetic route to the carbocyclic core of the cornexistins is reported. The route is highlighted by a Diels-Alder cycloaddition/oxidative cleavage strategy to generate the central highly functionalized nine-member ring. A silyl-tethered ring-closing metathesis strategy is utilized to control trisubstituted alkene geometry.

Diels-Alder - oxidative cleavage - natural products - ring expansion - ring-closing metathesis - carbocycle

References

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